在老年人群中,尿液微量元素水平与抑郁症状之间的关联
Ying Zhang1, Junjiao Ping2, Dong Cui3
1Joint Laboratory of Psychiatric Genetic Research, The Third People's Hospital of Zhongshan City, Zhongshan 528451, Guangdong, China.
Experimental gerontology
|February 11, 2025
概括
尿铜水平升高与老年人抑郁症状增加有关. 接触铜量较高的男性的风险显著增加,这表明铜是抑郁症的潜在生物标志物.
科学领域:
- 环境健康 环境健康
- 老年精神病学是一门精神病学专业.
- 营养流行病学 营养流行病学
背景情况:
- 晚年抑郁症在老年人群中是一个重要的公共卫生问题.
- 微量元素失衡越来越多地与抑郁症有关,但研究主要集中在血液中的水平上.
- 这项研究调查了尿液微量元素与老年人抑郁症状之间的关联.
研究的目的:
- 确定尿液微量元素水平与60岁及以上个体抑郁症状之间的相关性.
- 探索尿液微量元素作为抑郁症的非侵入性生物标志物的潜力.
主要方法:
- 一种分层,多阶段的随机抽样方法招募了来自中国南部的400名老年参与者.
- 使用患者健康问卷-9项 (PHQ-9) 评估抑郁症状.
- 尿液中微量元素度使用诱导合血质谱法进行测量,并使用后勤回归和限制立方线 (RCS) 模型进行分析.
主要成果:
- 在391名参与者中,尿液中的铜水平与抑郁症状有积极的相关性.
- 尿铜的高三位数与抑郁症状的可能性增加有关,特别是在男性中.
- 尿铜值为8.22μg/g,表明抑郁症风险在此水平以上逐渐增加.
结论:
- 尿铜水平与老年人抑郁症状的发展有关.
- 男人似乎对铜暴露对抑郁症状的影响更敏感.
- 尿铜是一种有希望的,非侵入性指标,用于评估与环境暴露相关的抑郁风险.
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