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Updated: May 28, 2025

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
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CYP3A4活性变化可能导致abemaciclib的分层代谢

Xiao-Yu Xu1, Jing Chen1, Zhong-Xi Chen1

  • 1Institute of Molecular Toxicology and Pharmacology, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, PR China.

International journal of biological macromolecules
|February 11, 2025
PubMed
概括

在CYP3A4酶的遗传变异显著影响abemaciclib是如何代谢. 了解这些CYP3A4 (cytochrome P450 3A4) 遗传差异对于个性化药物治疗至关重要.

关键词:
活动抑制 活动抑制在 CYP3A4 中.遗传的多态化 遗传多态化

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Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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