运动改变了人类白色脂肪组织中炎症和基质代谢的分子概况
Maria F Pino1, Pieter Dijkstra1, Katie L Whytock1
1Translational Research Institute, AdventHealth, Orlando, Florida, United States.
American journal of physiology. Endocrinology and metabolism
|February 11, 2025
概括
短期有氧训练通过减少炎症和增强脂质代谢来改善白色脂肪组织 (WAT) 质量. 这些分子适应在WAT中发生的独立于体重或脂肪质量的变化.
科学领域:
- 代谢适应的过程
- 分子生物学分子生物学
- 运动生理学 运动生理学
背景情况:
- 白色脂肪组织 (WAT) 对于能量恒温至关重要,其功能障碍与肥胖和代谢疾病有关.
- 虽然运动训练可以改善新陈代谢健康,但WAT中的特定分子机制仍然不清楚.
- 了解WAT的分子变化是阐明运动对健康的好处的关键.
研究的目的:
- 在久坐不动的超重女性进行短期有氧训练干预后,研究腹部皮下WAT的分子适应性.
- 利用多原子方法 (RNA-seq,蛋白质组学,蛋白质组学) 来识别基因表达,蛋白质丰度和蛋白质酸化的变化.
- 要确定这些分子适应是否独立于体重或脂肪质量的变化而发生.
主要方法:
- 在基线和监督有氧训练3周后,从久坐不动的超重妇女 (n=6) 收集了腹部皮下WAT活检.
- 进行RNA测序 (RNA-seq) 来分析转录组变化.
- 全球蛋白质组学和蛋白质组学被用来评估蛋白质和酸盐的变化.
主要成果:
- 有氧训练诱导了1527个转录,154个蛋白质和144个酸盐的显著变化.
- 训练减少了与炎症和细胞外矩阵组件相关的转录和蛋白质的丰富性.
- 训练增加了参与脂肪酸化和脂解的转录和蛋白质的丰富性.
结论:
- 短期有氧训练通过减少局部炎症和增加脂质代谢来提高WAT质量.
- 这些有益的分子适应在WAT中发生的独立于体重或脂肪质量的显著变化.
- 研究结果表明,改善WAT质量有助于有氧运动的整体健康益处.
更多相关视频
06:08Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
Published on: May 19, 2023
2.0K
02:55Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention
Published on: October 6, 2023
1.3K
相关概念视频
01:24Muscle Recovery and Fatigue
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
01:27Exercise and Muscle Performance
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
01:20Exercise and Cardiovascular Response
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
01:24Overview of Lipid Metabolism
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
01:24Obesity
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
01:26Type II Diabetes I: Introduction
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...