Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Renal Corpuscle01:20

Renal Corpuscle

1.6K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.6K
Aging01:26

Aging

35
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
35
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

48
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
48
Hormonal Regulation01:33

Hormonal Regulation

32.8K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.8K
Nephrons01:10

Nephrons

2.1K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.1K
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

338
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
338

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Endothelial dysfunction in human diabetic vascular complications: translating single-cell transcriptomics into therapeutic opportunities.

Molecular medicine (Cambridge, Mass.)·2026
Same author

Targeting the Lipid Metabolism Proteins FASN and GPAM in Alveolar Type II Cells Decreases Lung Metastasis.

Cancer discovery·2026
Same author

Author Correction: PHGDH heterogeneity potentiates cancer cell dissemination and metastasis.

Nature·2026
Same author

Hypernatremia Enhances Transient Outward Potassium and Late Sodium Currents in a Mouse Model of Long QT Syndrome Type 3.

bioRxiv : the preprint server for biology·2025
Same author

A fully iPS-cell-derived 3D model of the human blood-brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions.

Nature neuroscience·2025
Same author

Drivers of hospital costs in ANCA-associated vasculitis patients with long-term follow-up-a real-world cost analysis.

Clinical kidney journal·2025

相关实验视频

Updated: May 28, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.2K

在老化脏中的内皮功能障碍.

Mila Borri1, Marleen E Jacobs2,3, Peter Carmeliet1,4

  • 1Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, VIB, Leuven, Belgium.

American journal of physiology. Renal physiology
|February 11, 2025
PubMed
概括
此摘要是机器生成的。

脏衰老会损害脏内皮细胞 (REC),导致慢性脏病 (CKD). 准REC衰老和新陈代谢可能为衰老的脏和CKD患者提供新的治疗方法.

关键词:
它们是内皮细胞的内皮细胞.内皮质功能障碍 在内皮质功能障碍脏衰老 衰老 脏衰老代谢 代谢 代谢 代谢年老疗法 年老疗法.

更多相关视频

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

9.7K
Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

27.3K

相关实验视频

Last Updated: May 28, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.2K
Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

9.7K
Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

27.3K

科学领域:

  • 老年学是一门学科.
  • 腎臟病學 (nephrology) 是一種醫學專業.
  • 血管生物学 血管生物学

背景情况:

  • 全球人口老龄化带来了重大的健康挑战,特别是影响器官功能的与年龄相关的疾病.
  • 脏对衰老非常敏感,表现出功能减弱,再生能力受损和受伤风险增加,导致慢性脏病 (CKD) 的患病率更高.
  • 内皮细胞 (REC) 的功能障碍是衰老的关键因素,影响血管完整性和整体健康.

研究的目的:

  • 审查老化脏血管系统的结构和功能变化.
  • 描述老化的内皮细胞表型,并专注于驱动内皮细胞 (EC) 衰老的分子/代谢变化.
  • 概述针对EC的老年疗法,特别是调节新陈代谢的老年疗法,以寻找潜在的治疗应用.

主要方法:

  • 文献综述,重点关注衰老对脏大血管和小血管区的影响.
  • 陈旧内皮的表型描述,包括分子和代谢重新连接.
  • 针对EC衰老和新陈代谢的老年治疗策略的概述.

主要成果:

  • 衰老显著改变的结构和功能,RECs经历衰老和代谢重编程.
  • 脏内皮细胞衰老有助于血管功能障碍和微环境变化.
  • 针对EC新陈代谢的疗法显示出减轻与年龄相关的衰退的前景.

结论:

  • 了解REC衰老和衰老对于开发针对衰老和CKD的干预措施至关重要.
  • 向EC衰老和新陈代谢为改善老龄人口脏健康提供了潜在的治疗途径.
  • 复苏性REC可以使CKD患者受益,并提高老年移植的结果.