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在老化脏中的内皮功能障碍
Mila Borri1, Marleen E Jacobs2,3, Peter Carmeliet1,4
1Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, VIB, Leuven, Belgium.
American journal of physiology. Renal physiology
|February 11, 2025
概括
脏衰老会损害脏内皮细胞 (REC),导致慢性脏病 (CKD). 准REC衰老和新陈代谢可能为衰老的脏和CKD患者提供新的治疗方法.
科学领域:
- 老年学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血管生物学 血管生物学
背景情况:
- 全球人口老龄化带来了重大的健康挑战,特别是影响器官功能的与年龄相关的疾病.
- 脏对衰老非常敏感,表现出功能减弱,再生能力受损和受伤风险增加,导致慢性脏病 (CKD) 的患病率更高.
- 内皮细胞 (REC) 的功能障碍是衰老的关键因素,影响血管完整性和整体健康.
研究的目的:
- 审查老化脏血管系统的结构和功能变化.
- 描述老化的内皮细胞表型,并专注于驱动内皮细胞 (EC) 衰老的分子/代谢变化.
- 概述针对EC的老年疗法,特别是调节新陈代谢的老年疗法,以寻找潜在的治疗应用.
主要方法:
- 文献综述,重点关注衰老对脏大血管和小血管区的影响.
- 陈旧内皮的表型描述,包括分子和代谢重新连接.
- 针对EC衰老和新陈代谢的老年治疗策略的概述.
主要成果:
- 衰老显著改变的结构和功能,RECs经历衰老和代谢重编程.
- 脏内皮细胞衰老有助于血管功能障碍和微环境变化.
- 针对EC新陈代谢的疗法显示出减轻与年龄相关的衰退的前景.
结论:
- 了解REC衰老和衰老对于开发针对衰老和CKD的干预措施至关重要.
- 向EC衰老和新陈代谢为改善老龄人口脏健康提供了潜在的治疗途径.
- 复苏性REC可以使CKD患者受益,并提高老年移植的结果.
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