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在监测人群中,便免疫化学测试 (FIT) 连续一轮便血红蛋白值的变化

Gemma Mortell¹, Kate Wooldrage², Gwen A Murphy²

¹Department of Surgery and Cancer, Imperial College London - St Mary's Campus, London, UK g.mortell@imperial.ac.uk.

BMJ open gastroenterology

|February 11, 2025

概括

随着时间的推移,便免疫化学测试 (FIT) 值的变化可能表明晚期结直肠瘤 (ACN) 的风险. FIT结果的连续增加表明ACN检测率更高,这表明结直肠癌监测中的风险分层可能存在.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
预防医学预防医学

背景情况:

结肠直肠癌 (CRC) 查和监测对于早期检测和预防至关重要.
术后的监测结肠镜检查可能是繁的.
便免疫化学测试 (FIT) 为监测CRC风险提供了一个不那么侵入性的替代方案.

研究的目的:

调查多轮FIT定量值变化与高级结直肠瘤 (ACN) 检测之间的关联.
探索串行FIT结果在CRC监控中分层个体风险的潜力.

主要方法:

一项前性诊断准确性研究,涉及4412名年龄在60-72岁的参与者,接受监测结肠镜检查.
定量FIT是在结肠镜检查后的1,2,3年进行的.
参与者根据FIT值的变化 (绝对差异≥4μg/g) 和第3轮的阳性度进行分组.

主要成果:

在FIT值没有变化的组中,ACN检测率最低 (4.7%).
随着FIT值的连续增加和第3轮的积极结果的组显示出最高的ACN检测率 (32.6%).

结论:

稳定的FIT结果与ACN的低风险有关.
在串行回合中增加FIT值与检测ACN的可能性更高相关.
连续的FIT轮可能是个性化CRC监控策略的有价值工具.

关键词:

癌症流行病学癌症流行病学结肠腺瘤 - 结肠腺瘤结肠癌是一种大肠癌.结肠癌查结肠癌查

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