艾滋病毒感染者的综合冠状动脉CT血管学:系统性审查和元分析
Tarin Phillips1,2, Gregory M Blake3, Jonathan A Aun4,5
1Department of Cardiology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA tarincphillips.do@gmail.com.
BMJ open
|February 11, 2025
概括
与对照人群相比,艾滋病毒感染者 (PLWH) 患非化冠状动脉斑块的患病率更高. 需要进一步的研究来探索定量测量和狭窄和化斑块患病率的潜在差异.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 艾滋病毒感染者 (PLWH) 可能有心血管疾病的风险增加.
- 之前的研究表明,关于PLWH冠状动脉斑块患病率和狭窄的结果是相互矛盾的.
研究的目的:
- 系统地审查和对PLWH冠状动脉样硬化的观察性研究进行元分析.
- 用冠状动脉CT血管造影 (CTA) 来估计冠状动脉斑块特征的聚合效应大小.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 在主要数据库 (PubMed,Embase,Web of Science等) 中进行全面的文献搜索. ) 的情况.
- 包括比较成人PLWH与对照者的冠状动脉CTA发现的研究.
主要成果:
- PLWH显示,非化斑块的患病率显著更高 (OR=1.61).
- 在部分化斑块,狭窄性患病率或细分参与评分 (SIS) 中没有发现显著差异.
- 两组之间的斑块发病率或细分狭窄度评分 (SSS) 没有显著差异.
结论:
- PLWH表现出非化冠状动脉斑块的更大流行率.
- 需要进一步研究量化CTA测量,并调查狭窄和化斑块患病率的潜在差异,以增加统计能力.
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