在情绪调节期间,双极性障碍患者的未受影响一级亲属的神经子组在情绪调节期间
Hanne Lie Kjærstad1,2, Florien Ritsma1, Klara Coello2
1Neurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric Centre Copenhagen, Mental Health Services, Capital Region of Denmark, and Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
Psychological medicine
|February 11, 2025
概括
两组双相情感障碍患者的亲属在情绪调节期间表现出不同的大脑活动. 这可能解释了先前的研究差异,并突出了面部表情认知受损的积极表情作为潜在的双相情感障碍内因型.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 情绪失调是双相情绪障碍 (BD) 中潜在的内分类型.
- 以前对未受影响亲属 (UR) 的功能磁共振成像 (fMRI) 研究显示了不一致的结果.
- 这项研究研究了UR在情绪调节过程中的神经子组.
研究的目的:
- 在情绪调节期间,在UR中识别不同的神经子组.
- 探索这些子组的临床和认知相关性.
- 调和之前对BD内型的fMRI研究中不一致的发现.
主要方法:
- 在情绪调节任务期间,对71名UR和66名健康对照 (HC) 进行了fMRI扫描.
- 层次集群分析确定了基于预定义兴趣区域的神经活动的子组.
- 分组在神经激活,人口统计,病史和认知表现方面进行了比较.
主要成果:
- 两个UR小组出现了:小组1 (前额叶皮和杏仁体的低活性) 和小组2 (所有区域的过度活性).
- 第一个子组表现出情绪调节较差,童年创伤较高.
- 第二小组表现出更多的焦虑,功能低下,对恐惧的面孔保持高度警. 这两个小组都对正面人脸的识别有损.
结论:
- 在UR中确定的神经子组可能解释了先前的fMRI研究中的差异.
- 这两小组在情绪调节期间都显示出异常的神经活动,但是在相反的方向上.
- 对积极面部表情的认知障碍被认为是双相情感障碍的广泛内分类型.
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