2型糖尿病的禁食模仿饮食降低了心肌甘油酸含量:12个月的随机对照试验
Paul R Roos1, Elske L van den Burg2, Marjolein P Schoonakker2
1Department of Radiology, Leiden University Medical Center (LUMC), the Netherlands.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|February 11, 2025
概括
在12个月的时间里,模仿禁食的饮食 (FMDs) 在2型糖尿病患者中显著降低了心肌甘油酸含量 (MTGC). 这一发现表明,口病可能改善心脏代谢,降低心血管风险.
科学领域:
- 心血管医学 心血管医学
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
背景情况:
- 2型糖尿病 (T2D) 增加了心血管疾病 (CVD) 的风险,部分原因是肌心硬化症 (心脏中的脂肪积累).
- 禁食模仿饮食 (FMDs) 提供与禁食相似的潜在代谢益处,但强度较低.
- 心肌甘油三含量 (MTGC) 是心脏代谢的关键指标,也是降低T2D心血管疾病风险的潜在目标.
研究的目的:
- 评估结构化禁食模仿饮食 (FMD) 计划对2型糖尿病患者心肌甘油酸含量 (MTGC) 的影响.
- 在12个月的时间内使用磁共振光谱 (MRS) 评估MTGC的变化.
- 为了确定口疫的干预是否对心脏新陈代谢产生有利的影响,与通常的护理相比.
主要方法:
- 一项随机对照试验,涉及100名2型糖尿病患者,主要使用甲福明或不使用降糖药.
- 参与者被分配到一个口炎组 (5天/月口炎+常规护理) 或对照组 (仅常规护理).
- 心脏1H-MRS被用来测量MTGC在基线,6个月和12个月. 每组13名参与者的数据在12个月后被分析.
主要成果:
- 口疫组在12个月内显示MTGC显著减少 (-0.235%MTGC,p=0.027).
- 对照组在MTGC (0.143%MTGC,p=0.236) 中没有显著变化.
- 与对照组 (p=0.018) 相比,口和口腔炎组中MTGC的减少在统计学上是显著的.
结论:
- 坚持类似禁食的饮食计划可以有效地降低2型糖尿病患者的心肌甘油酸含量.
- 这种MTGC的减少表明对心脏代谢有积极的影响.
- 口病是缓解T2D患者心血管风险的一个有希望的策略.
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