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Updated: May 28, 2025

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pH和缓冲剂对基质结合和cis-aconitate脱碳酶催化物的作用

Mingming Zhao1, Chutao Chen2, Wulf Blankenfeldt1,3

  • 1Department of Structure and Function of Proteins, Helmholtz Centre for Infection Research, Braunschweig, Germany.

Scientific reports
|February 11, 2025
PubMed
概括

酸盐缓冲器可以抑制cis-aconitate脱碳酶 (ACOD1) 的活性. 优化缓冲和pH值揭示了动力学见解,表明多个质子化histidines对于这种itaconic酸合成酶的基质结合至关重要.

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