饮食炎症指数和代谢功能障碍之间的关系与儿童的脂肪性肝病相关
Fateme Amiri1, Jalal Moludi1, Touraj Ahmadi Jouybari2
1Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Scientific reports
|February 11, 2025
概括
通过饮食炎症指数 (DII) 测量的炎症性饮食与儿童更严重的代谢功能障碍相关的脂肪性肝病 (MASLD) 有关. 通过抗炎饮食降低DII得分可能会改善MASLD的结果.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 营养科学 营养科学
- 代谢健康 代谢健康
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 越来越多地在儿童中被发现.
- 人们怀疑饮食模式在MASLD的发展和进展中起着重要作用.
研究的目的:
- 调查饮食炎症指数 (DII) 与儿科患者MASLD的严重程度之间的关联.
- 为了确定饮食诱导的炎症是否与患有MASLD的儿童的肝硬化和纤维化相关.
主要方法:
- 一项对125名儿科MASLD患者 (7-18岁) 的横截面研究.
- 通过147项食物频率调查问卷评估饮食摄入量,以计算DII分数.
- 肝硬化和纤维化通过 transabdominal 超声波和 FIB-4 指数进行评估.
主要成果:
- 与抗炎饮食 (低DII) 儿童相比,具有炎症饮食 (高DII) 的儿童患重型肥胖症的几率明显更高 (OR:4.11).
- 每个单位增加的DII得分与严重肥胖症的几率增加了2.6倍,FIB-4得分增加了0.006倍.
- 针对潜在的混因素进行了调整.
结论:
- 减少DII分数的饮食修改是治疗儿科MASLD的一个有希望的策略.
- 抗炎饮食与MASLD儿童肝硬化症和纤维化症的严重程度降低有关.
- 向饮食诱导的炎症可能会改善儿科MASLD的临床结果.
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