病毒载量可以预测有症状的先天性CMV感染吗? 一个系统的审查和元分析
Serena Salomè1, Roberta Gammella2, Clara Coppola2
1Division of Neonatology, University of Naples Federico II, Via Pansini 5, 80131, Naples, Italy. serena.salome@unina.it.
European journal of pediatrics
|February 11, 2025
概括
血液和尿液中的高细胞巨乳病毒 (CMV) 病毒载荷可能表明新生儿患有症状性先天性CMV疾病. 需要进一步的研究来证实这种关联并确定风险值.
科学领域:
- 病毒学 病毒学
- 新生儿医学 新生儿医学
- 传染性疾病 传染性疾病
背景情况:
- 细胞巨乳病毒 (CMV) 是最常见的先天性感染,早期诊断对治疗至关重要.
- 虽然10%的感染新生儿在出生时表现出症状,但疾病可能在婴儿期晚些时候表现出来.
- 以前的研究表明,高血病毒载量和症状性CMV之间存在相关性,但结果不一致,对其他体液的数据缺乏.
研究的目的:
- 研究不同生物液体中的病毒载量与症状性先天性CMV疾病之间的关联.
- 为了确定较高的CMV病毒载荷是否与新生儿的症状呈现相关.
主要方法:
- 在Medline,Embase和SCOPUS (1976-2024) 中进行了系统的文献搜索.
- 包括的研究报告了中位数和平均病毒载荷.
- 使用元分析方法汇集了差异中位数的估计,比较了有症状和无症状的婴儿.
主要成果:
- 分析包括11项研究,其中血液分析为796名患者,尿分析为919名患者.
- 患有症状的婴儿在血液中表现出明显更高的CMV病毒载荷 (汇总的中位数差异:1.77×104 IU/mL).
- 在有症状的婴儿的尿液中观察到更高的病毒载荷趋势 (汇总的中位数差异:339.7×104 IU/mL).
结论:
- 初步发现表明,血液和尿液中的高CMV病毒载荷与新生儿的症状性先天性CMV疾病之间存在潜在的关联.
- 需要进行更广泛和更一致的研究来验证这些发现.
- 确定特定的病毒载荷值是必要的,以更好地预测临床疾病风险的婴儿.
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