系统性炎症与中风后患者的肠道微生物群多样性有关
Yoshihiro Yoshimura1, Hidetaka Wakabayashi2, Fumihiko Nagano3
1Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital, 760 Magate, Kikuyo, Kikuchi, Kumamoto, 869-1106, Japan. hanley.belfus@gmail.com.
European geriatric medicine
|February 11, 2025
概括
系统性炎症对中风后患者的肠道微生物群多样性产生负面影响. 较高的炎症评分与降低的香农指数和操作分类单元 (OTU) 丰富度相关,表明肠道微生物群的多样性较小.
科学领域:
- 微生物组研究的研究.
- 炎症和疾病 炎症和疾病
- 神经康复疗法 神经康复疗法
背景情况:
- 对肠道微生物组在健康结果中的作用越来越感兴趣.
- 系统性炎症与住院患者的肠道微生物群多样性之间的关系尚不清楚.
- 专注于中风后康复患者.
研究的目的:
- 调查系统性炎症与肠道微生物群多样性之间的关联.
- 具体地研究这种关系在接受中风后康复的患者中.
主要方法:
- 对156名中风后康复患者的横截面研究.
- 使用修改的格拉斯哥预后分数 (mGPS) 评估系统性炎症.
- 肠道微生物群多样性通过香农指数,OTU丰富度和Faith的PD进行评估.
- 多重线性回归分析对混因子进行了调整.
主要成果:
- 在mGPS和香农指数 (β = -0.177) 和OTU丰度 (β = -0.208) 之间发现了显著的负相关性.
- 较高的mGPS得分与下肠道微生物群多样性相关.
- 没有观察到mGPS和Faith的家族遗传多样性 (PD) 之间有显著的关联.
结论:
- 系统性炎症与中风后患者的肠道微生物群多样性减少显著相关.
- 肠道微生物群的定量和质量方面都受到炎症的影响.
- 研究结果强调了在中风康复中考虑肠道健康的重要性.
相关概念视频
Chronic Bowel Disorders: Introduction
384
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
384
Irritable Bowel Syndrome I: Introduction
231
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
231
What is Monogastric Digestion?
70.4K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.4K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
304
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
304
Inflammatory Bowel Disease II: Crohn's Disease
171
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
171


