儿童和青少年多药耐药结核病的全球负担
Yanyan Zhong1, Huiru Xie2, Fucheng Cai2
1Department of Pediatrics, Huazhong University of Science and Technology Hospital, Wuhan, China.
Pediatric research
|February 11, 2025
概括
在儿童和青少年中,多抗药结核病 (MDR-TB) 的全球发病率在1990年至2019年期间显著增加. 这种增长在低社会经济水平的地区尤为明显,突出显示了对有针对性的干预措施的迫切需要.
科学领域:
- 全球健康 全球健康
- 流行病学 流行病学
- 儿童传染病 儿童传染病
背景情况:
- 多药耐药结核病 (MDR-TB) 构成了日益严重的全球卫生挑战.
- 多抗药性结核病发病率的趋势需要持续监测,以制定有效的公共卫生战略.
研究的目的:
- 确定儿童和青少年 (<20岁) 中MDR-TB发病率的全球趋势.
- 通过分析不同地区和社会经济地位的MDR-TB负担,为战略健康规划提供信息.
主要方法:
- 从2019年全球疾病负担 (GBD) 数据库中对MDR-TB负担数据的二次分析.
- 分析了全球,区域和国家层面的数据,按社会人口统计指数 (SDI) 五分位数分层,从1990年到2019年.
主要成果:
- 在2019年,全球约有67,711例MDR-TB事件发生在20岁以下的个人中.
- 全球MDR-TB发病率从1990年到2019年增加,在低和低中等SDI地区显著增加.
- 在撒哈拉以南非洲,东欧和南亚观察到的发病率最高. 在5岁以下的儿童中,死亡率和DALY率更高.
结论:
- 在过去的三十年中,儿童和青少年的MDR-TB的全球负担有所增加,特别是在较低的SDI地区.
- 紧急的,协作性的研究和干预对于解决这个不断升级的儿科健康危机至关重要.
- 多抗药性结核病负担与SDI呈负相关性,强调疾病影响的差异.
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