使用组织工程方法进行脏再生的当前策略:系统审查
Parham Torabinavid1, Mohammad Hossein Khosropanah1, Ashkan Azimzadeh1
1Pediatric Urology and Regenerative Medicine Research Center, Gene, Cell and Tissue Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
BMC nephrology
|February 11, 2025
概括
组织工程对生物工程脏具有前景,因为末期脏疾病的增加. 提高临床前研究设计对于将这些再生医学进展转化为临床实践至关重要.
科学领域:
- 再生医学是一种再生医学.
- 生物材料科学 生物材料科学
- 器官工程 器官工程是指器官工程.
背景情况:
- 末期脏病 (ESRD) 的发病率不断上升,需要除透析和移植外的新性脏替代疗法.
- 组织工程为开发生物工程脏提供了一个有希望的途径,解决了供体稀缺和移植并发症的问题.
- 脱细胞化器官和再生医学是一个尖端领域,在器官修复和更换方面具有显著的潜力.
研究的目的:
- 系统地审查用于脏组织工程研究的临床前数据.
- 确定成功从实验室转化为临床实践的关键参数.
- 评估生物工程脏发育研究的现状.
主要方法:
- 在没有语言限制的情况下,PubMed的系统文献搜索.
- 对完整的环形和内置程序进行专注的评估.
- 评估关键参数:细胞播种,脱细胞化,再细胞化和生物材料.
主要成果:
- 从1484个获取的脏中,包括了105项研究,使用来自八种物种的脏.
- 整个器官和丢弃的人类脏的脱细胞化都进行了,并创建了支架 (水凝,床单,溶液).
- 评估了脱细胞化方法 (物理,化学,酶) 和支架灭菌,以及各种重新细胞化协议和细胞类型.
结论:
- 脏组织工程的临床前研究正在推动再生医学的发展.
- 在临床前研究设计的改进对于组织工程技术的成功临床转化至关重要.
- 需要进一步的研究来弥合实验室发现和生物工程脏临床应用之间的差距.
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