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双重阳性非侵蚀性狼性关节炎:黄斑还是没有?
1Department of Internal Medicine-Rheumatology, Faculty of Medicine, Mustafa Kemal University, Alahan, Hatay, 31060, Turkey. mete.pekdiker@hotmail.com.
Advances in rheumatology (London, England)
|February 11, 2025
概括
这项研究发现,一些狼性关节炎 (LA) 患者出现了类风湿性关节炎 (RA) 样症状和双重血清阳性. 这些案例凸显了区分LA和RA的诊断挑战.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 狼性关节炎 (LA) 的分类缺乏共识.
- 研究的LA患者与类风湿性关节炎 (RA) 有临床和血清学相似之处.
研究的目的:
- 为了研究患有狼性关节炎 (LA) 的患者,他们表现出类似于类风湿性关节炎 (RA) 的临床和血清学特征.
主要方法:
- 审查了528个系统性红斑狼 (SLE) 患者档案 (2017-2022年).
- 包括的患者 (n=8) 患有非侵蚀性外围关节炎 (>6个月) 和双重血清阳性 (RF和抗CCP).
- 放射和超声波证实了非侵蚀性关节炎;不包括药物诱导的狼和其他类风湿性疾病.
主要成果:
- 确定了8名女性患者 (平均年龄48.5岁),中位数为SLE (12年) 和关节炎 (7年) 持续时间.
- 所有人都患有手/手腕关节炎;光敏感性是最常见的SLE症状 (n=8).
- 危及生命的参与 (LTI) 的低频率;观察到高射频/抗CCP标位;rituximab在三名患者中实现了缓解.
结论:
- 患者呈现了SLE,而不是鲁综合征,尽管长期患有关节炎和双重血清阳性.
- 狼性炎和其他LTI的频率非常低.
- 狼性关节炎在临床和血清学上可能与RA无法区分,因此需要进一步的前性研究来准确定义.
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