儿童甲状腺癌诊断和治疗的最新进展
Joel A Vanderniet1,2,3, Noemi A Fuentes-Bolanos4,5, Yoon Hi Cho1,2
1Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Journal of paediatrics and child health
|February 12, 2025
概括
儿童甲状腺癌的护理正在推进新的诊断工具和向疗法,朝着个性化治疗的方向发展. 这种转变旨在改善结果,同时减少与传统方法相关的终身并发症.
科学领域:
- 儿科瘤学 儿科瘤学
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 传统的小儿甲状腺癌管理依赖于成人数据,往往导致激进的手术和放射性 (RAI) 治疗,并可能产生长期副作用.
- 了解儿科瘤生物学,诊断和向治疗的进展使得更个性化的方法成为可能.
研究的目的:
- 审查儿童甲状腺癌生物学,诊断和护理模型的最新发展.
- 突出从一般化到疾病特定的管理策略的演变.
主要方法:
- 在过去五年内出版的文学作品的叙事评论.
- 由儿童甲状腺癌专家组成的多学科团队综合信息.
主要成果:
- 超声波上的儿科甲状腺结节的标准化风险分层工具正在出现,需要进一步验证.
- 体和生殖系基因变异在诊断,手术规划和新辅助/辅助疗法方面变得越来越重要.
- 在低风险病例中,叶切除术可能与甲状腺全切除术提供类似的结果,并发症较少.
- 对于晚期疾病,可以使用分子向疗法,包括新辅助解和重新敏感化RAI耐药瘤.
结论:
- 随着儿童特异性数据的可用性,儿童甲状腺癌的治疗正在迅速发展.
- 复杂性日益增加,需要加强跨学科合作,在患者护理中共享决策.
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