铁碳酸 (FCM) 相关的低酸血症 (HPP):一个系统性审查
Joseph Magagnoli1, Kevin Knopf1, William J Hrushesky1
1The Southern Network on Adverse Reactions (SONAR), Clinical Pharmaceutical Outcomes Sciences Department, University of South Carolina College of Pharmacy, Columbia, South Carolina, USA.
American journal of hematology
|February 12, 2025
概括
铁性碳酸 (FCM) 铁可以引起低度血症 (HPP),导致骨疼痛和骨折. 监测酸盐水平和考虑替代铁治疗对于患者安全至关重要.
科学领域:
- 药物监督 药物监督 药物监督
- 临床药理学 临床药理学
- 矿物质的新陈代谢.
背景情况:
- 铁炭酸糖 (FCM) 是一种用于治疗缺铁性贫血 (IDA) 的静脉注射铁制剂.
- 自2015年以来,越来越多的报告将FCM与低酸血症 (HPP) 联系起来.
- 临床表现和与FCM相关的HPP发生率需要审查.
研究的目的:
- 审查临床表现和与铁性碳酸盐糖相关的低酸血症的发生率.
- 评估FCM相关的HPP作为药物不良反应的临床意义.
- 为改善患者安全和管理提供建议.
主要方法:
- 对FDA不良事件报告,病例研究,观察数据库,临床试验,元分析和FDA标签的全面审查.
- 分析的重点是确定常见的HPP表现和发病率.
- 与FCM和其他静脉注射铁配方之间的HPP率的比较.
主要成果:
- 与FCM相关的HPP是一种显著的不良药物反应.
- 常见的表现包括软弱,疲劳,骨头疼痛,肌肉疼痛,骨髓损伤和骨折.
- 临床试验显示,使用FCM的HPP率为50-92%,而使用其他静脉注射铁制品的HPP率为2-8%.
结论:
- 需要更新FCM标签,以应对HPP的风险,包括骨髓损伤和骨折.
- 建议包括在FCM治疗前和治疗期间监测血清酸盐.
- 临床医生需要对与FCM相关的HPP,其管理挑战以及替代的IV铁选项进行教育.
相关概念视频
01:36Carbohydrate Metabolism
10.5K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.5K
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
275
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
275
01:30Heart Failure V: Medical Management
642
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
642
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
812
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
812
01:21Hyperosmolar Hyperglycemic State
28
Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
28