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芬兰RRMS初始治疗模式的演变 (2013-2022):来自全国多发性硬化病注册的见解

Henrik Ahvenjärvi¹, Elina Jokinen², Matias Viitala³

¹Research Unit of Clinical Medicine, Neurology, University of Oulu, Oulu, Finland.

Brain and behavior

|February 12, 2025

概括

芬兰复发性复发性多发性硬化症 (RRMS) 的治疗已经转向更早的诊断和高效的疾病修饰治疗 (DMT). 从2013年到2022年观察到的这种趋势表明患者预后可能有所改善.

科学领域:

神经学神经学
免疫学免疫学免疫学
临床试验临床试验

背景情况:

复发性复发性多发性硬化症 (RRMS) 治疗格局正在演变.
关于芬兰最初的RRMS治疗模式的数据有限.

研究的目的:

分析芬兰RRMS初始疾病修饰治疗 (DMT) 的趋势 (2013-2022年).
调查治疗延迟,影响DMT选择的因素和DMT切换模式.
评估COVID-19大流行对RRMS治疗的影响.

主要方法:

从芬兰MS登记册中对数据进行了回顾性分析.
将DMT分为中效 (meDMT) 和高效 (heDMT) 的类别.
包括2479名符合研究标准的患者.

主要成果:

作为初始疗法,高效DMT (heDMT) 的显著增加 (6.9%至43.7%).
诊断延迟的中位数大幅减少 (10.1至4.6个月).
较高的疾病活性和较年轻的年龄与heDMT启动相关;COVID-19没有延迟治疗.

结论:

芬兰的RRMS治疗显示出转向早期诊断和高效的DMT的转变.
这一趋势表明了改善患者预后的潜力.
高效的DMT在初始和后续治疗中越来越受青.

关键词:

根据COVID-19的情况,延迟诊断的延迟诊断是一个问题.药物治疗是药物治疗.多发性硬化症多发性硬化症经常收集的健康数据.

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