在患有童年发作狼性炎的患者中早期不良结果的临床和实验室风险因素 - 一个单一中心的回顾性研究
Wei Qijiao1,2, Huang Fujia3, Yang Bing4
1Department of Pediatrics, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Immunity, inflammation and disease
|February 12, 2025
概括
儿童发病的狼性炎 (LN) 带有皮疹或口腔,高24小时尿道总蛋白 (UTP) 和低白蛋白预测早期预后不佳. 积极的蛋白尿控制是儿童LN更好的结果的关键.
科学领域:
- 儿科脏病学 儿科脏病学
- 自免疫性疾病 自免疫性疾病
- 临床研究 临床研究
背景情况:
- 童年发病的狼性炎 (LN) 通常比成人形式更严重.
- 与成年人相比,儿科LN的预后早期指标的理解较少.
- 识别早期反应不良的风险因素对于及时干预至关重要.
研究的目的:
- 调查与狼性炎儿童诱导治疗早期反应不良相关的临床和实验室风险因素.
- 帮助临床医生制定针对儿科LN的优化治疗策略.
主要方法:
- 从2012年至2018年期间诊断出LN的99名儿童的临床数据的回顾性分析.
- 完全缓解 (CR) 的定义基于正常化实验室值和24小时尿道总蛋白 (UTP) <150毫克.
- 在3个月后实现CR (良好的预后) 和未实现CR (不良预后) 的儿童之间的临床和实验室指标的比较.
主要成果:
- 预后不佳的儿童 (n=84) 与预后良好的儿童 (n=15) 相比,发疹 (32.1%) 和口腔 (81.0%) 的发病率更高.
- 在预后不佳的组中观察到24小时升高的UTP (2.46g vs. 0.56g) 和血清肌素 (53.0 vs. 39.0 umol/L).
- 较低的血清白蛋白水平 (28.7 g/L与34.5 g/L) 与早期不良结果有显著的关联.
结论:
- 皮疹和口腔是儿童LN早期预后不佳的重要指标,需要进行彻底的全身评估.
- 高24小时UTP是儿科LN早期不良结果的强有力的积极预测因素.
- 通过积极的蛋白尿控制实现快速性缓解对于改善儿童发病性狼性炎的预后至关重要.
相关概念视频
Factors Affecting Renal Clearance: Renal Impairment
48
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
48
Factors Affecting the Risk of Infection
10.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
10.8K
Renal Corpuscle
1.6K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.6K
Pulmonary Tuberculosis I
220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220
Immunodeficiency Diseases
895
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
895
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
43
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
43


