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全免疫性炎症和类风湿性关节炎全因死亡率的综合分析:基于数据库的方法,1999-2018年

Muradil Mardan¹, Huoliang Zheng¹, Qingyin Xu¹

¹Spine Center, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Frontiers in immunology

|February 12, 2025

概括

全免疫炎症值 (PIV) 预测了类风湿性关节炎 (RA) 患者的死亡率,显示了与值效应的非线性关系. 较高的PIV水平表明在特定值以下的死亡风险增加,这表明其用于个性化RA治疗.

科学领域:

类风湿病学类风湿病学
免疫学免疫学免疫学
生物标志物研究生物标志物研究

背景情况:

类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,与全身炎症和死亡风险增加有关.
全免疫炎症值 (PIV) 是一种新的免疫-炎症活性生物标志物,但其在RA中的预后作用尚未研究.

研究的目的:

评估PIV与RA患者全因死亡率之间的关联.
调查非线性关系并确定PIV对RA死亡率的值影响.

主要方法:

利用了1999-2018年国家健康和营养检查调查 (NHANES) 中1882名RA患者的数据.
计算PIV并使用多变量Cox模型,受限立方线和细分回归分析其与死亡率的关联.
为了验证,进行了卡普兰-梅尔曲线和子组分析.

主要成果:

增加的PIV水平与RA患者全因死亡率的增加显著相关 (P趋势<0.001).
观察到一种非线性关系,在PIV = 302时具有值效应. 死亡风险在这个值以下增加,在这个值以上下降.
卡普兰-梅尔曲线显示,随着PIV四分位数的增加,生存率明显下降 (P < 0.001).

结论:

PIV是RA患者全因死亡率的独立预测因素,表现出非线性关联和值效应.
这些发现表明,PIV可以成为分层死亡风险和指导RA个性化治疗策略的宝贵生物标志物.

关键词:

考克斯的比例危险模型.尼汉斯 (NHANES) 是一个名人.泛免疫性炎症的价值所有原因的死亡率.预后生物标志物预后生物标志物类风湿性关节炎是一种类风湿性关节炎.分段回归分析细分回归分析系统性炎症系统性炎症

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