来自呼吸道微生物群的Corynebacteria调节炎症反应,并与肺部肺炎球菌负担的减少有关
Caroline Bergenfelz1, Phuong Do1, Liv Larsson1
1Department of Translational Medicine, Division of Experimental Infection Medicine, Lund University, Lund, Sweden.
一些呼吸道细菌,Corynebacterium propinquum和C. pseudodiphtheriticum,通过调节炎症和减少细菌负担,可以防止严重的肺炎球菌感染.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 呼吸系统健康 呼吸系统健康
背景情况:
- 正常的呼吸道微生物群包括Corynebacterium propinquum和C. pseudodiphtheriticum.
- 这些细菌与减少的呼吸道感染有关,但它们的作用未被描述.
研究的目的:
- 调查Corynebacteria在呼吸系统健康和疾病中的作用.
- 为了确定Corynebacteria是否影响宿主对Streptococcus pneumoniae的反应.
主要方法:
- 用Corynebacteria注射人类细胞和小鼠,然后用Streptococcus pneumoniae.挑战.
- 评估炎症反应和细菌负担,使用各种测试 (西斑,细胞因子阵列,流细胞计,盘子计数).
主要成果:
- 皮质细菌耐受性很好,并诱导了短暂的炎症反应.
- 用Corynebacteria调节炎症反应和减少小鼠肺炎球菌负担的鼻.
- 科里尼细菌没有影响肺炎球菌的获取,但可能会防止严重感染.
结论:
- 科里尼细菌调节了对肺炎球菌的炎症反应.
- 科里尼细菌的存在与呼吸道肺炎球菌负担降低有关.
- 科里尼细菌显示出保护严重肺炎球菌感染的潜力.
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