与Streptococcus suis相关的新生儿脑膜炎和败血症:特征,抗菌素耐药性和公共卫生影响
Giovanna Fusco1, Rubina Paradiso2, Lorena Cardillo1
1Department of Animal Health, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples, Italy.
Frontiers in microbiology
|February 12, 2025
概括
这项研究报告了第一例导致新生儿脑膜炎和败血症的Streptococcus suis病例. 确定的菌株表现出抗菌素耐药性,突出显示了新生儿护理需要保持警的必要性.
科学领域:
- 微生物学 微生物学
- 新生儿医学 新生儿医学
- 传染性疾病 传染性疾病
背景情况:
- 新生儿脑膜炎和败血症是新生儿的严重感染.
- 瑞杆菌 (Streptococcus suis) 是一种已知的病原体,主要通过动物传播感染成年人.
- 新生儿感染很少见,这使得这个病例特别值得注意.
研究的目的:
- 报告新生儿中首个已记录的Streptococcus suis脑膜炎和败血症病例.
- 鉴定出S. suis菌株的抗微生物耐药性特征.
- 强调在新生儿感染中考虑S. suis的重要性,并评估抗菌素敏感性.
主要方法:
- 脑膜炎和败血症在早产婴儿的临床诊断.
- 从脑脊液和血液中分离和识别细菌.
- 下一代测序用于菌株特征 (血清型,序列类型,耐药性基因,毒性因子).
- 与现有的S. suis菌株进行基因组比较分析.
主要成果:
- 在一个32天的早产婴儿中,Streptococcus suis (血清型2,ST1) 被确定为病原体.
- 该菌株携带了 ermB 和 tet(W) 基因,从而产生对宏类和四环素的耐药性.
- 基因组分析揭示了与当地人类和猪菌株的高度相似性,并确定了20个毒性因素.
- 这是新生儿中首次报告的S. suis脑膜炎/败血症病例.
结论:
- 由于Streptococcus suis的新生儿脑膜炎和败血症可能会发生,并且可能与抗菌素耐药性有关.
- 越来越多的S. suis对宏类,林科萨米德和四环素的耐药性是全球关注的问题.
- 早期识别和抗菌素敏感性测试对于有效管理新生儿S. suis感染至关重要.
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