来自内菌的生物活性类衍生物Trichoderma citrinoviride
Yan-Ping Xia1, Yan Xie2, Li Rao3
1Department of Pharmacy, Nanan People's Hospital of Chongqing, Chongqing, China.
Frontiers in microbiology
|February 12, 2025
概括
三种来自Trichoderma citrinoviride的三种新型基类衍生物显示出有前途的抗氧化和抗炎作用. 化合物2和3表现出显著的激素清除活性,而化合物1显示出抗炎性潜力.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
背景情况:
- 从Coptis chinensis等药用植物中分离出来的Trichoderma citrinoviride等内菌是生物活性化合物的丰富来源.
- 索尔比基利诺酸是一种具有多种生物活动的真菌代谢物.
研究的目的:
- 从内生菌Trichoderma citrinoviride中分离和表征新的基类衍生物.
- 评估分离化合物的抗氧化和抗炎潜力.
主要方法:
- 使用色谱技术分离和净化化合物.
- 通过光谱数据分析阐明结构,包括NMR,ECD和DFT计算.
- 在LPS诱导的RAW 264.7巨细胞中使用DPPH激素清除试验和氧化抑制试验进行生物活性评估.
主要成果:
- 分离了三种新的酸盐衍生物 (酸盐酸盐A-C) 和三种已知的化合物.
- 化合物1-4表现出抗氧化活性,而化合物2和3显示出强大的基因清除能力,与 Askorbic 酸相比.
- 化合物1通过抑制氧化生产,表现出抗炎活性.
结论:
- 该研究确定了具有显著抗氧化和抗炎性能的新型类类衍生物.
- 这些发现突出了Trichoderma citrinoviride衍生化合物的治疗潜力,用于控制氧化应激和炎症.
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