腺菌症中异位子宫内膜和异位子宫内膜的激素受体概况:系统性审查
Alison Maclean1,2, Laura Tipple3, Emily Newton4
1Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
Human reproduction open
|February 12, 2025
概括
与正常子宫内膜相比,腺菌病变显示出雌激素受体 (ER) 表达的增加,特别是ERα. 由于数据矛盾和研究局限性,腺肌病中的激素受体概况需要进一步调查.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 妇科病理学 妇科病理学
- 分子生物学分子生物学
背景情况:
- 腺菌病变表达激素受体,表明卵巢类固醇激素的作用.
- 与正常子宫内膜相比,对腺菌症症状的不有效的激素治疗表明,与正常子宫内膜相比,可能存在不同的激素反应和受体配置.
研究的目的:
- 系统地审查和分析腺菌病变的激素受体配置,与eutopic子宫内膜相比.
主要方法:
- 从PubMed,Ovid Medline,Embase,Scopus和Cochrane图书馆数据库中对研究进行系统审查和主题分析.
- 包括人类研究报告原始数据的荷尔蒙受体 (雌激素,孕,雄激素) 在腺菌病变与eutopic子宫内膜.
- 使用纽卡斯尔-太华评分系统进行了偏差分析.
主要成果:
- 11项蛋白质组和1项转录研究,涉及555名参与者,符合资格标准.
- 持续增加的雌激素受体 (ER),特别是ERα,表达在腺菌病变中被观察到,特别是在分泌阶段和子宫内膜功能.
- 在孕激素受体 (PR) 表达方面发现了相互矛盾的结果,没有报告显著差异或降低水平. 关于雄激素受体 (AR) 表达的数据很少.
结论:
- 升高的ERα水平表明雌激素在腺菌病变中占主导地位,与局部超雌激素主义理论一致.
- 月经周期时间的异质性和缺乏特定区域的分析限制了对孕激素耐药性的结论.
- 未来的研究应该专注于明确的队列,以最大限度地减少偏见,并对治疗点和理解病原体的激素受体配置文件进行强有力的探索.
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