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脂质纳米粒子输送系统用于正常化瘤微环境和瘤血管结构

Heejin Ha¹, Yonghyun Choi^1,2, Na-Hyeon Kim³

¹School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea.

Biomaterials research

|February 12, 2025

概括

这项研究引入了一种新的pH敏感脂质体系统 (OD_PSL@AKB),可以向瘤提供氧气和拉苏普罗塔菲布. 它有效地对抗瘤缺氧和异常血管系统,提高治疗效率.

科学领域:

生物医学工程生物医学工程
癌症生物学癌症生物学
药物输送系统药物输送系统

背景情况:

瘤生长依赖于血管生成,导致血管系统异常.
瘤微环境 (TME) 缺氧加剧了亲血管原因子分泌 (例如,VEGF).
低性TME损害了放射治疗,免疫治疗和化疗的疗效.

研究的目的:

开发一种pH敏感脂质体 (PSL) 系统,用于同时提供氧气 (OD) 和拉苏普罗塔菲布 (AKB-9778).
研究该系统减轻瘤缺氧和正常化血管系统的能力.
评估对治疗疗效的影响.

主要方法:

开发一种pH敏感脂质体 (PSL) 系统,OD_PSL@AKB.
氧气 (OD) 和拉苏普罗塔菲布 (AKB-9778) 的同时传递给瘤.
在低氧内皮细胞/癌细胞共同培养中进行评估.

主要成果:

该OD_PSL@AKB系统迅速响应酸性TME.
缓解缺氧并抑制血管内皮生长因子 (VEGF) 的分泌.
恢复VE-cadherin的表达并使瘤血管正常化.

结论:

OD_PSL@AKB证明了可以使瘤血管正常化的潜力.
这种方法可能会提高癌症治疗的疗效.
准TME缺氧是癌症治疗的一个有希望的策略.

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