在2型糖尿病中改变了大脑功能网络连接和拓
Weiwei Ni1, Weiyin Vivian Liu2, Mingrui Li3
1Physical Examination Centre, Central People's Hospital of Zhanjiang, Zhanjiang, China.
Frontiers in neuroscience
|February 12, 2025
概括
2型糖尿病 (T2DM) 显著改变大脑网络连接和拓,影响认知功能. 这些大脑变化可能作为T2DM相关认知障碍的成像生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 内分泌学 在内分泌学.
背景情况:
- 已知2型糖尿病 (T2DM) 可以加速大脑衰老.
- 在T2DM中观察到大脑功能网络连接的中断,但机制尚不清楚.
研究的目的:
- 调查T2DM驱动的大脑功能网络连接和拓学的改变.
- 探索T2DM中大脑网络异常和认知功能之间的关系.
主要方法:
- 休息状态功能磁共振成像 (rs-fMRI) 和3D-T1WI用于85名T2DM患者和67名健康对照 (HCs).
- 大脑功能网络是使用Dosenbach地图集构建的,并通过DPABI-NET工具包通过图形理论进行分析.
- 进行了临床,神经心理 (MoCA) 和实验室测试.
主要成果:
- 与HC患者相比,T2DM患者在主要大脑网络 (DMN,FPN,SCN,VAN,SMN,VN) 内/之间功能连接性降低.
- 全球网络分析显示,T2DM中最短路径长度增加,集群/全球/本地效率下降.
- 节点分析表明多个大脑区域的中心性和效率降低,与MoCA分数相关.
结论:
- T2DM与大规模大脑功能网络连接和拓学的显著异常有关.
- 这些网络变化可能作为T2DM相关认知障碍的成像生物标志物.
- 研究结果提供了对T2DM认知缺陷背后的神经病理过程的见解.
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