花可以通过调节肠道微生物群和改善肠道屏障完整性来缓解性结肠炎
Wen-Lin Pang1,2, Tian-Gang Li1,3, Yin-Ying Wang1,3
1Yunnan Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, China.
Frontiers in cellular and infection microbiology
|February 12, 2025
概括
花 (SC) 显示了通过减少炎症和改善肠道健康来治疗性结肠炎 (UC) 的潜力. 这种传统中医药可能为这种具有挑战性的疾病提供新的治疗途径.
科学领域:
- 胃肠病学和肝病学
- 药理学和制药科学 药理学和制药科学
- 微生物学 微生物学
背景情况:
- 性结肠炎 (UC) 是一个全球性的健康挑战,治疗选择有限,需要新的治疗策略.
- 传统中医药 Saussurea costus (SC) 显示出有前途的抗菌和抗炎性质,但其在UC中的机制尚不清楚.
研究的目的:
- 在性结肠炎 (UC) 的小鼠模型中研究Saussurea costus (SC) 的治疗潜力和潜在机制.
- 确定SC的活性成分,并评估其对肠道炎症,屏障功能和肠道微生物群的影响.
主要方法:
- 超高性能液态染色学-四极飞行时间质谱学 (UHPLC-QTOF-MS) 用于活性成分的识别.
- 德克斯硫酸 (DSS) 诱导性结肠炎小鼠模型,以评估SC疗效和对肠粘膜屏障的影响.
- 免疫光学,西部斑点和16S rRNA基因测序以分析炎症标记物,屏障蛋白和肠道微生物群组成.
主要成果:
- SC含有,氨酸,单氨酸,Lucidenic酸M,和pyroglutamic酸. 这就是为什么.
- 在大肠炎小鼠中,SC治疗改善了组织损伤,减少了促炎细胞因子 (TNF-α,IL-1β,IL-8,IL-18) 和增加了抗炎细胞因子 (IL-10,IL-22).
- 通过逆转ZO-1和奥克卢丁的下调,SC恢复了肠道屏障的完整性,通过减少蛋白质菌和增加乳酸菌来调节肠道微生物群.
结论:
- 花 (SC) 显示出对性结肠炎 (UC) 的显著治疗潜力.
- SC通过减轻炎症,恢复肠道屏障功能和重新平衡肠道微生物群组成来发挥其作用.
- 这些发现为推进SC作为UC治疗的新疗法策略提供了机制基础.
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