时间趋势和对系统性红斑狼死亡率的人口统计洞察,1999-2020年
Ansaam Daoud1, Loai Dweik2, Omer Pamuk1
1University Hospitals/Case Western Reserve University, Cleveland, Ohio.
Arthritis care & research
|February 12, 2025
概括
系统性红斑狼 (SLE) 的死亡率从1999年到2020年在所有人口统计数据中显著下降. 然而,差异仍然存在,非洲裔美国妇女和南方州的SLE死亡率更高.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 类风湿病学 类风湿病学
背景情况:
- 系统性红斑狼 (SLE) 是一种具有显著发病率和死亡率的慢性自身免疫性疾病.
- 以前的研究表明,SLE死亡率有所下降,但强调了持续的差异.
- 了解SLE死亡率的人口和地理趋势对于有针对性的干预至关重要.
研究的目的:
- 分析与美国SLE死亡相关的人口特征.
- 在过去二十年 (1999-2020年) 中绘制SLE死亡率的国家和地理趋势图.
- 为了确定特定的人口和地区不成比例地受到SLE死亡率的影响.
主要方法:
- 利用疾病预防控制中心 (CDC) 广泛的流行病学研究在线数据 (WONDER) 数据库,从1999年到2020年对SLE死亡情况进行了分析.
- 按年龄调整的死亡率 (AAMR) 按性别,种族/族裔和州分层计算.
- 采用线性回归模型来评估SLE死亡率的趋势和SLE与非SLE死亡率的比率.
主要成果:
- 在1999年至2020年期间,在美国确定了27213例SLE死亡.
- 与男性和其他种族/种族群体相比,女性和非裔美国人表现出更高的AAMR,特别是非裔美国女性.
- 在所有组中观察到SLE AAMR的显著下降,SLE与非SLE AAMR的比率持续下降;南方州的度更高.
结论:
- 自1999年以来,与SLE相关的死亡率在不同的人口群体中持续下降.
- 非洲裔美国人,尤其是女性,以及南部地区的SLE死亡率仍然不成比例.
- 持续监测和有针对性的公共卫生战略是必要的,以解决SLE结果的持续差异.
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