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Updated: May 28, 2025

A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model
08:24

A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model

Published on: November 25, 2022

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作为对α-Synuclein聚合和相关毒性的潜在调节剂,硫法梅拉

Priyanka Singh1, Nagesh Y Kadam1, Rajlaxmi Panigrahi2

  • 1Council of Scientific and Industrial Research─Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India.

ACS chemical neuroscience
|February 12, 2025
PubMed
概括

研究人员确定了硫法梅拉,拉索斯特醇和塔莫西芬作为抑制α-synuclein (α-Syn) 纤维化的药物,这是帕金森病 (PD) 的标志. 在PD模型中,硫法梅拉有效降低了α-Syn聚合和毒性.

关键词:
凯诺哈比迪斯伊莱根斯 (Caenorhabditis elegans) 是一种PD的模型.帕金森病是帕金森氏症的一种疾病.在SH-SY5Y细胞中.粉胺聚合物 粉胺聚合物硫法马雷辛是一种硫化物.α-synuclein 是一种同核蛋白.

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