东亚和南亚特有的血压轨迹和心血管疾病
So Mi J Cho1,2,3, Sarah Urbut1,2,4, Yunfeng Ruan1,2
1Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.J.C., S.U., Y.R., W.E.H., R.B., M.C.H., P.N.).
Hypertension (Dallas, Tex. : 1979)
|February 12, 2025
概括
心血管疾病 (CVD) 风险因血压 (BP) 模式不同而在东亚和南亚人之间有所不同. 了解高血压轨迹中的这些差异对于有针对性的高血压查和心血管疾病预防策略至关重要.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 遗传学 遗传学 是一个
背景情况:
- 心血管疾病 (CVD) 风险概况在不同亚洲族裔亚组之间表现出显著的差异.
- 高血压负担是导致心血管疾病风险差异的一个关键因素.
- 了解终身血压 (BP) 轨迹对于描述这些差异至关重要.
研究的目的:
- 描述东亚和南亚个体的终身血压 (BP) 轨迹.
- 为了在这些子组中比较血压轨迹和发生动脉样硬化心血管疾病风险之间的关联.
- 为不同的亚洲人群提供量身定制的高血压查和管理策略.
主要方法:
- 利用了来自148,872名参与者的英国生物库数据和初级保健数据.
- 作为年龄,性别和自我认同的种族的函数,适合生命历程BP轨迹.
- 在年轻成年,中年和晚年,时间平均的缩血压 (SBP) 和腹缩血压 (DBP) 与发生动脉样硬化心血管疾病风险的确定的关联.
主要成果:
- 与东亚人相比,南亚人在生命早期表现出更高的血压轨迹.
- 年轻成人SBP与南亚人心血管疾病风险增加有关 (OR,1.41),但不是东亚人.
- 在每个子组中,中年和晚年SBP与特定的CVD结果 (周围动脉疾病,缺血性中风,心肌梗塞) 有差异相关.
结论:
- 东亚和南亚人群之间存在着不同的BP轨迹.
- 这些BP模式与发生心血管疾病风险的年龄差异相关.
- 分解亚洲子组对于开发个性化的高血压管理和心血管疾病预防计划至关重要.
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