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Updated: May 28, 2025

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
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对于用于生物直角成像的四二基探针的设计策略

Aiwen Yu1, Xinyu He1, Tianruo Shen2

  • 1Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province and Frontiers Science Center for Disease Related Molecular Network West China Hospital, Sichuan University, Chengdu 610041, China. haoxingwu@scu.edu.cn.

Chemical Society reviews
|February 12, 2025
PubMed
概括

素化探针正在推进生物对等化学,用于精确的生物成像和传感. 设计和合成方面的创新正在扩大其光谱范围和诊断中的应用.

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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