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相关概念视频

Cerebrum: Anatomical Overview I01:26

Cerebrum: Anatomical Overview I

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The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
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Sutures of the Skull01:22

Sutures of the Skull

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The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
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Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

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Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
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Neurulation01:30

Neurulation

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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
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Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

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The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor...
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Lobes of the Cerebrum01:22

Lobes of the Cerebrum

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The cerebral cortex, a critical structure of the brain, is intricately divided into two hemispheres, each consisting of four distinct lobes: occipital, temporal, frontal, and parietal. These lobes function cooperatively to regulate various cognitive and sensory functions, forming the basis of our complex neural capabilities.
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements....
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Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
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在人类大脑皮层发育过程中的初级硫形成.

Miyu Kumagai1, Toru Kanahashi1, Jun Matsubayashi2

  • 1Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Anatomical record (Hoboken, N.J. : 2007)
|February 12, 2025
PubMed
概括

早期人类大脑的形形成发生在怀孕15周之前,关键形出现的时间比以前想象的要早. 这项高分辨率的MRI研究揭示了产前诊断和神经发育研究的关键时机.

关键词:
人类大脑皮层 大脑皮层磁共振成像技术的使用初级硫酸盐的形成.

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科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 放射学 放射学是一门学科.

背景情况:

  • 人类大脑形形成对认知功能至关重要.
  • 了解这些结构的精确时间和发展对于识别神经发育异常至关重要.

研究的目的:

  • 为了确定初始人类大脑形形成的精确时间.
  • 描述早期发育的硫的形态和形态特征.
  • 为改善产前诊断和神经发育障碍研究奠定基础.

主要方法:

  • 在33个胎儿样本 (11-16周妊娠期) 上利用高分辨率磁共振成像 (MRI).
  • 采用3D重建来精心绘制大脑表面和内部结构的地图,识别和比较样本中的.
  • 建立了基于冠状长度 (CRL) 的各种硫的准确检测时间.

主要成果:

  • 识别的初始形形成比以前报告的更早:形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形形
  • 观察到与CRL相比,大多数硫酸盐的长度和深度线性增加,但有一些例外.
  • 建议硫可能在一段距离内同时形成,而不是逐渐延长.

结论:

  • 通过使用高分辨率的MRI,确定了早期人类大脑发育的准确时间.
  • 这些发现为产前查和理解神经发育障碍的起源提供了关键的参考.
  • 这项研究强调了先进的成像技术在早期发育神经科学中的潜力.