瑞宁-血管酶系统在糖尿病病中的作用:最新情况
Andre Sanglard1, Barbara Castello Branco Miranda1, Ana Luiza França Vieira1
1Interdisciplinary Laboratory of Medical Investigation, Unit of Pediatric Nephrology, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Mini reviews in medicinal chemistry
|February 12, 2025
概括
糖尿病脏病 (DN) 涉及氨酸-血管素系统 (RAS). 准ACE2-Ang-(1-7)-Mas轴为治疗糖尿病损伤提供了新的希望.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病病 (DN) 是末期病 (ESRD) 的主要原因之一.
- 氨酸-血管氨系统 (RAS) 在DN病变发生过程中发挥着关键作用.
- 了解RAS调制是开发有效DN治疗的关键.
研究的目的:
- 审查氨酸- ангиотензин系统 (RAS) 在糖尿病病 (DN) 中的作用.
- 突出目前针对DN的RAS的治疗方法.
- 探索DN管理的新兴治疗视角.
主要方法:
- 进行了到2024年3月的叙事文献综述.
- 在Scopus,PubMed,Scielo和Cochrane数据库中进行了搜索.
- 专注于经典和替代RAS轴和DN的新疗法方法.
主要成果:
- 经典的RAS轴 (ACE,Ang II,AT1受体) 通过血管收缩和纤维化加剧了DN.
- 目前的治疗方法 (ACE抑制剂,ARBs) 通过阻断经典轴来减缓DN进展.
- 替代的ACE2-Ang-(1-7)-Mas轴显示出脏保护作用,抵消Ang II.
- 像SGLT2抑制剂这样的新兴疗法也有利于DN患者.
结论:
- ACE 抑制剂,ARB 和 SGLT2 抑制剂是当前 DN 的支柱.
- ACE2-Ang-(1-7)-Mas轴代表了DNA的一个有前途的治疗点.
- 将替代RAS轴的临床前发现转化为临床实践对于未来的DN治疗改进至关重要.
关键词:
ACE 抑制剂 是 一种 ACE 抑制剂.在ACE2激活器中,ACE2激活器糖尿病脏病 糖尿病脏病更多的受体受体.ангиотензин II 的使用血管素- ((1 - 7)) 的作用.血管新生素- ((1-9).氨酸 - ангиотензин 系统更多相关视频
10:37Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
101
08:15Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
Published on: May 10, 2024
512
相关概念视频
01:25Antihypertensive Drugs: Direct Renin Inhibitors
508
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
508
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
492
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
492
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
396
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
396
01:33Hormonal Regulation
33.0K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.0K
01:13Introduction to Urinary System
2.3K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
2.3K
01:30Antihypertensive Drugs: Angiotensin II Receptor Blockers
600
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
600