维生素C可以防止电子烟气溶暴露引起的记忆障碍
Karem H Alzoubi1,2, Omar F Khabour3, Nour Al-Sawalha2
1Department of Pharmacy Practice and Pharmacotherapeutics, University of Sharjah, Sharjah, UAE.
Current neuropharmacology
|February 12, 2025
概括
电子烟使用会通过引起氧化应激来损害记忆力. 维生素C (VitC) 管理保护了电子烟引起的记忆缺陷,并恢复了老鼠的抗氧化剂水平.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 毒理学 毒理学 毒理学
背景情况:
- 电子烟 (EC) 诱导氧化应激,破坏反应性氧物种 (ROS) 和抗氧化酶的平衡,从而损害记忆力.
- 维生素C (VitC) 是一种强大的抗氧化剂,具有细胞保护性质,有效地清除自由基.
研究的目的:
- 在大鼠模型中调查维生素C (VitC) 对因电子烟 (EC) 暴露引起的记忆障碍的潜在保护作用.
- 评估EC暴露和VitC治疗对氧化应激生物标志物和大脑衍生神经营养因子 (BDNF) 在海马中的影响.
主要方法:
- 鼠被暴露于EC四周,同时每天口服维生素C (100mg/kg/bw).
- 空间学习和记忆被使用辐射臂水迷宫治疗后评估.
- 氧化应激生物标志物 (GSSG,GSH,GSH/GSSG比率,TBARS,Catalase,GPx) 和BDNF的海马水平被量化.
主要成果:
- 电子烟暴露显著影响了短期和长期记忆 (p < 0.05).
- EC暴露降低了GPx,SOD,GSH,GSH/GSSG比率和BDNF的水平,同时增加了GSSG水平 (p <0.05).
- 维生素C的使用抵消了EC引起的记忆缺陷,并恢复了氧化应激生物标志物和BDNF的正常水平.
结论:
- 电子烟使用导致显著的短期和长期记忆障碍.
- 维生素C有效地预防了这些不良影响,通过其抗氧化性质证明了它对EC诱导的神经毒性的保护作用.
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