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Updated: May 28, 2025

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
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Published on: July 24, 2021

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创新疗法:在使用混合物设计和多目标优化与NSGA-II算法对抗多耐药细菌感染方面取得重大突破

Meriem Adouane1,2, Nabil Kadri2,3, Nourelimane Benzitoune1,2

  • 1Laboratoire de Gestion et Valorisation des Ressources Naturelles et Assurance Qualité (LGVRNAQ), Faculté des Sciences de la Nature et de la Vie et des Sciences de la Terre, Université de Bouira, 10000 Bouira, Algeria.

Current topics in medicinal chemistry
|February 12, 2025
PubMed
概括

诸如胡卜素和类等海洋化合物与抗生素协同作用,对抗多药耐药细菌. 这种方法对开发新疗法来对抗具有挑战性的细菌感染充满希望.

关键词:
抗生素耐药性 抗生素耐药性创新的治疗方法.海洋代谢物中的海洋代谢物.多目标优化多目标优化有协同作用的相互作用.

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Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
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