GLP-1受体激活剂的耳鼻喉学副作用
Faizaan I Khan1, Sebastian Guadarrama-Sistos Vazquez1,2, Zain Mehdi2
1Texas A&M School of Engineering Medicine, Houston, Texas, U.S.A.
The Laryngoscope
|February 12, 2025
概括
类似葡萄糖-1受体激动剂 (GLP-1 RA) 药物与耳鼻喉科副作用,如GERD和甲状腺癌有关. 塞马格卢提德和利拉格卢提德显示出各种不良事件的显著信号,需要监测.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药物监督 药物监督 药物监督
- 内分泌学 在内分泌学.
背景情况:
- 葡萄糖样-1受体激动剂 (GLP-1 RA) 药物越来越多地用于减肥和糖尿病.
- 有关与GLP-1RA使用相关的潜在耳鼻喉学不良事件 (AE) 存在担忧.
- 对这些AE进行全面评估对于患者安全至关重要.
研究的目的:
- 评估与GLP-1受体激动剂 (GLP-1RA) 药物相关的耳鼻喉学不良事件 (AE) 的频率和意义.
- 确定需要密切监测的特定GLP-1RA和AE.
主要方法:
- 食品和药物管理局的不良事件报告系统 (FAERS) 数据库的回顾性分析.
- 包含从药物批准到2023年底的exenatide,liraglutide,dulaglutide,semaglutide和tirzepatide的数据.
- 报告几率比率 (ROR) 和比例报告比率 (PRR) 的计算,以识别重要的AE信号.
主要成果:
- 在所有研究的GLP-1RA中,共报告了9,746次副作用.
- 甲状腺髓癌 (MTC) 和乳头甲状腺癌 (PTC) 在几乎所有药物中显示出最高的显著信号.
- 胃食道逆流性疾病 (GERD) 对所有评估的药物也显示出高,显著的信号. 塞马格卢提德和利拉格卢提德与多种耳鼻喉脏病的显著信号有关,包括贝尔和.
结论:
- GLP-1RA与一系列耳鼻喉学不良事件有关.
- 在所有评估的GLP-1RA中观察到GERD,MTC和PTC的显著信号.
- 塞马格卢提德和利拉格卢提德与特定的耳鼻喉副作用有显著的关联,这强调了需要密切监测的必要性.
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