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通过皮肤刺激耳道迷走神经抑制精神压力诱导的皮质醇释放-对炎症状况的潜在影响

Ely Cuberos Paredes¹, Domenica Goyes¹, Sadie Mak¹

¹Department of Biomedical Sciences, Burrell College of Osteopathic Medicine, Las Cruces, New Mexico, USA.

Physiological reports

|February 12, 2025

概括

通过皮肤进行耳道迷走神经刺激 (taVNS),可以通过降低皮质醇水平来帮助控制慢性炎症. 这种非侵入性技术在改善葡萄糖皮质体功能和潜在地缓解炎症状况方面表现有前途.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
内分泌学在内分泌学.

背景情况:

慢性炎症状况与葡萄糖皮质激素水平升高和反应能力降低有关.
被皮质激素释放激素 (CRH) 调节的下丘脑-垂体-上腺 (HPA) 轴在压力反应和炎症中起着关键作用.
葡萄糖皮质激素功能的失调可以加剧慢性炎症过程.

研究的目的:

为了研究通过皮肤进行耳道迷走神经刺激 (taVNS) 对压力期间葡萄糖皮质激素水平的影响.
探索taVNS在调节HPA轴和改善慢性炎症条件下的葡萄皮质皮质素功能障碍方面的潜力.
评估taVNS对健康成年人和患有牛皮的患者的唾液皮质醇水平的影响.

主要方法:

一项随机对照研究,涉及12名健康成年人,将taVNS与假taVNS进行比较.
在这两种条件下,参与者都接受了心理算术压力测试 (MAST).
在整个会议中测量了唾液皮质醇水平,心率和心率变化 (HRV).
一名牛皮病患者每天接受taVNS三个月,并进行白天唾液皮质醇监测.

主要成果:

心理算术压力测试 (MAST) 成功诱导了同情激活,如心率增加和HRV改变所证明的.
在MAST期间的唾液皮质醇水平在taVNS条件下明显低于模拟taVNS条件 (p <0.05).
在一个牛皮患者中,每天在三个月内服用taVNS导致白天唾液皮质醇水平降低.

结论:

通过皮肤进行耳道迷走神经刺激 (taVNS) 可以有效地降低皮质醇对急性压力的反应.
taVNS显示出作为治疗干预的潜力,用于管理与慢性炎症相关的葡萄皮质激素功能障碍.
需要进一步的研究来阐明精确的机制,例如阻碍前腔室核 (PVN) 中的CRH释放神经元的抑制,这是taVNS的影响的基础.

关键词:

这是一种抗炎性反射反应.葡萄糖皮质类药物耐药性下丘脑-垂体-上腺轴牛皮是一种牛皮.

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