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Updated: May 28, 2025

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双重测序确定了ENU诱导的突变在雄性小鼠生殖细胞†中的独特特征

Danielle P M LeBlanc1, Gu Zhou1, Andrew Williams1

  • 1Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.

Biology of reproduction
|February 12, 2025
PubMed
概括

双重测序显示出对生殖细胞突变性测试的希望,检测MutaMice中的N-乙基-N-酸氨酸基因突变. 胚胎细胞突变机制似乎与体质组织不同.

关键词:
这就是 MutaMouse.基准剂量建模的基准剂量建模ecNGSS 这是一个很好的方法.错误纠正的测序错误纠正的测序.胚胎细胞是发生在胚胎中的胚胎细胞.突变频谱中的突变突变易感性的突变易感性转基因动物测定试验

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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