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含有葡萄糖酸的寡糖的有针对性的益生菌应用通过微生物交叉养网络促进便细菌的生长

Hiroki Negishi¹, Ayumi Ichikawa¹, Saori Takahashi¹

¹Wellness Science Labs, Meiji Holdings Co., Ltd., Tokyo 192-0919, Japan.

The ISME journal

|February 12, 2025

概括

马尔托和乳酸可以选择性地促进有益的 Faecalibacterium 的生长. 这些益生菌通过支持Faecalibacterium通过涉及Parabacteroides的新型交叉养途径来增强肠道健康.

科学领域:

微生物学微生物学
人类肠道微生物组
营养科学营养科学

背景情况:

肠道微生物群对人类健康至关重要,其中Faecalibacterium prausnitzii是关键的有益细菌.
传统的益生菌通常会增加Bifidobacterium,但对其他有益的微生物缺乏特异性,例如Faecalibacterium.

研究的目的:

确定新的益生菌化合物,专门促进有益的肠道细菌的生长,特别是Faecalibacterium prausnitzii.
通过已识别的化合物来研究Faecalibacterium选择性促进的基础机制.

主要方法:

在体外便培养以选益生菌化合物.
一个人类干预研究 (n=27) 涉及马尔托酸补充剂.
机械研究,包括对微生物交叉养途径的分析.

主要成果:

马尔托酸和乳酸被确定为特异性促进菌生长的化合物,在体外和体内.
马尔托酸补充剂显著增加了人类的Faecalibacterium丰富度,其有效性与最初的Parabacteroides水平有关.
阐明了一条交叉养路径,其中Parabacteroides将葡萄糖酸部分转化为葡萄糖酸,由Faecalibacterium利用.

结论:

含有葡萄糖酸的寡糖类,如马尔托酸和乳酸,是有希望的益生菌,用于针对性地增强 Faecalibacterium.
微生物相互作用和交叉养对于理解益生菌疗效至关重要.
这些发现为个性化微生物组调节策略开辟了新的途径.

关键词:

便细菌 (Faecalibacterium) 是一种存在于便中的细菌.帕拉巴克特罗伊德的使用交叉养交叉养是什么意思我们的肠道微生物群.马尔托比奥尼克酸是什么意思益生菌益生菌益生菌

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