影响系统冠状动脉风险估计2 (SCORE2) 的因素
Katarzyna Gryglewska-Wawrzak1, Maciej Banach2,3,4, Agata Sakowicz5
1Department of Cardiology and Congenital Diseases of Adults, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland. gryglewskak@gmail.com.
升高的E/E'和高灵敏度的心脏托罗素T (hs-cTnT) 独立预测高心血管疾病 (CVD) 风险. 心血管疾病风险增加与代谢年龄,NT-proBNP,hs-cTnT和较低的GFR相关.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 生物标志物研究 生物标志物研究
背景情况:
- 心血管疾病 (CVD) 构成严重的健康风险.
- 在无症状个体中早期识别风险因素对于预防至关重要.
- 十年风险评估对于管理心血管疾病事件至关重要.
研究的目的:
- 确定与10年心血管疾病 (CVD) 事件风险相关的关键因素.
- 调查40-69岁看似健康的成年人中高心血管疾病风险的预测因素.
- 为了将心血管疾病风险得分与特定的临床和生化标志物相关联.
主要方法:
- 148名没有确定的心血管疾病患者被分为低风险和高风险组使用SCORE2.
- 评估了心声学参数 (LAVI,LVMI,E/E'),心肺呼吸能力 (VO2AT,VO2max) 和生物标志物 (hs-cTnT,NT-proBNP,GFR).
- 进行了多次后勤回归和相关性分析,以确定独立的预测因素和关联.
主要成果:
- 高风险人群呈现左心室体积指数 (LAVI),左心室质量指数 (LVMI) 和E/E'的升高,同时氧气摄入量减少 (VO2AT,VO2max).
- 在高危患者中观察到更高的高灵敏性心脏托罗T (hs-cTnT) 和大脑尿素 (NT-proBNP) 的N终端前激素,以及更低的膜过率 (GFR).
- E/E' > 6.75 cm/s 和 hs-cTnT > 4.8 pg/ml 是高心血管疾病风险的独立预测因素. SCORE2与代谢年龄,hs-cTnT,NT-proBNP,GFR和VO2max相关.
结论:
- 升高的E/E'和hs-cTnT水平是高心血管疾病风险和非常高心血管疾病风险的独立预测因素.
- 10年内心血管疾病风险增加与更高的代谢年龄,高NT-proBNP和hs-cTnT以及降低GFR有关.
- 这些发现突出了无症状个体早期心血管疾病风险分层的潜在生物标志物.
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