2型糖尿病患者激素水平与视网膜病变之间的关联:一项横截面研究
Yu Meng1, Xueli Yang2,3, Yuxin Fan4
1Department of Ophthalmology, Tianjin Medical University General Hospital Airport Hospital, Tianjin, China.
Translational vision science & technology
|February 12, 2025
概括
性激素水平对糖尿病视网膜病变 (DR) 风险的影响在男性和女性中不同. 较高的丸激素和较低的益生菌素与男性的DR有关,而较高的FSH和LH与女性的DR有关.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病视网膜病变 (DR) 是糖尿病的一个主要并发症.
- 性激素在DR发育中的作用尚未完全理解.
- 了解这些关系可以为有针对性的预防和治疗策略提供信息.
研究的目的:
- 调查2型糖尿病患者的性激素水平与糖尿病视网膜病变 (DR) 患病率之间的关联.
- 探索这些协会中潜在的性别特异差异.
主要方法:
- 一项涉及2432名2型糖尿病患者的横截面研究.
- 测量了荷尔蒙水平,并诊断了DR.
- 用物流回归分析来确定各协会的赔率比率 (OR) 和95%置信区间 (CI).
主要成果:
- DR患病率为39.19%,没有显著的性别差异.
- 在男性中,增加的丸激素与更高的DR风险相关 (OR=1.64),而增加的益生菌素与较低的风险相关 (OR=0.65).
- 在女性中,较高的卵泡刺激激素 (FSH) (OR=2.22) 和黄素化激素 (LH) (OR=1.77) 与增加的DR患病率有关. 经更年期后患有高益生菌素的女性也显示DR风险增加 (OR=1.56).
- 观察到FSH和的暗示性剂量反应关系与DR患病率,尽管需要谨慎的解释.
- 其他危险因素包括低体重指数,吸烟,长时间的糖尿病和高静脉血压.
结论:
- 性激素在DR发育中起着重要作用,在男性和女性中观察到不同的影响.
- 和益生菌水平与男性的DR风险相关.
- 在绝经后的妇女中,FSH和丸激素显示了与DR的潜在剂量反应关系,需要进一步调查.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
Diabetes: Symptoms, Diagnosis, and Complications
499
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
499
Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
Pathophysiology of Diabetes
848
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
848
Carbohydrate Metabolism
10.7K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.7K


