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在患有脑小血管疾病的患者中,与认知相关的同时发生的大脑结构和功能变化

Wenwen Wang¹, Jing Huang¹, Runtian Cheng¹

¹First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

|February 12, 2025

概括

大脑小血管疾病 (CSVD) 显示了大脑结构和功能模式的逆转,特别是在左侧副海马环,尾状环和Rolandic部. 这表明结构和功能的脱,为CSVD机制提供了洞察力.

科学领域:

神经成像是一种神经成像.
神经学神经学
认知神经科学认知神经科学

背景情况:

大脑小血管疾病 (CSVD) 是一种常见的脑血管疾病,影响白质 (WM) 和深灰质.
认知障碍是CSVD的常见并发症,但潜在的神经生物学机制仍然不完全理解.

研究的目的:

在CSVD患者中调查与认知功能相关的同时发生的大脑结构和功能变化.
探索结构性赤字与CSVD中的功能变化之间的关系.

主要方法:

使用结构性和静止状态功能性MRI (fMRI),通过基于声素的形态学 (VBM) 分析灰质体积 (GMV),白质体积 (WMV) 和低频波动幅度 (ALFF).
30名正常对照组和65名心血管疾病患者 (33名有轻度认知障碍,32名没有) 进行了比较.
在CSVD患者中检查了认知得分和ALFF/VBM合在共同改变的区域之间的关联.

主要成果:

在三组中观察到GMV和WMV的显著差异.
在多个大脑区域发现了异常的ALFF,包括左侧门,罗兰 operculum,尾状和副海马圈.
在CSVD患者中,在左侧副海马回形,尾状和罗兰 operculum以及右上额叶中发现了结构缺陷 (VBM/WMV减少) 和功能过度激活 (ALFF增加) 的反转模式. 在左尾状体中注意到GMV和ALFF的独特增加.
异常的ALFF/VBM合与认知评估有显著的相关性.

结论:

脑神经疾病患者表现出大脑结构缺陷和功能激活的反向模式,表明结构功能脱.
这些发现增强了对CSVD认知障碍背后的病理生理机制的理解.

关键词:

低频波动的幅度低频波动的幅度大脑小血管疾病大脑小血管疾病认知障碍认知障碍是一种认知障碍.磁共振成像技术磁共振成像技术结构功能合器基于voxel的形态测量方法

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