基于非向的代谢学和蛋白质学研究对人体长期炼的研究
Wenqian Zhuang1, Yang Wang1, Xin Xu1
1Shanghai Institute of Doping Analyses, Shanghai University of Sport, Shanghai, 200438, China.
Applied biochemistry and biotechnology
|February 12, 2025
概括
定期长期运动通过改变代谢物和蛋白质对人体产生影响. 这项研究揭示了运动影响能量,氨基酸和核酸代谢,以及类固醇激素生物合成和炎症.
科学领域:
- 运动生理学 运动生理学
- 蛋白质组学是指蛋白质组学.
- 代谢学 代谢学 代谢学
背景情况:
- 定期炼提供了显著的健康益处,减少了心血管疾病,糖尿病和肥胖的风险.
- 长期运动引起的精确分子和生理变化尚未完全理解.
研究的目的:
- 研究长期炼习惯的个体的综合蛋白质和代谢变化.
- 阐明与持续体力活动相关的生理反应.
主要方法:
- 对早晨尿样进行非向的代谢学和蛋白质学分析.
- 使用液体色谱-质谱法 (LC-MS) 进行详细的分子分析.
- 对比了14个有定期炼习惯的人与10个久坐的对照人.
主要成果:
- 鉴定了404种不同的代谢物和394种不同的蛋白质.
- 长期运动显著影响能量代谢途径.
- 观察到氨基酸和核酸代谢,类固醇激素生物合成和炎症反应的改变.
结论:
- 长期的运动会在人体中引起广泛的分子变化.
- 研究结果提供了对运动在蛋白质和代谢层面的生理影响的更深入的理解.
- 建立了未来研究运动引起的健康益处机制的基础.
更多相关视频
07:34Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS
Published on: March 14, 2013
12.7K
07:26Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
Published on: October 17, 2018
20.1K
相关概念视频
Proteomics
7.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.2K
Exercise and Muscle Performance
1.3K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.3K
