将导致精神病的病变映射到人类大脑电路上,并提出刺激目标
Andrew R Pines1,2, Summer B Frandsen2, William Drew2
1Department of Psychiatry, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.
JAMA psychiatry
|February 12, 2025
概括
造成二次精神病的病变与以海马为中心的共同大脑电路相连. 这一发现可能指导未来的神经调节疗法治疗精神分裂症和相关疾病.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经学 神经学
背景情况:
- 确定与精神病有因果关系的大脑区域对于开发有效的精神分裂症治疗方法至关重要.
- 了解导致二次精神病的病变的功能连接,可以揭示常见的神经通路.
研究的目的:
- 为了确定导致二次精神病的病变是否在一个共同的大脑电路内共享功能连接.
- 根据病变连接模式,识别潜在的精神病神经调节目标.
主要方法:
- 一个病例控制研究,分析已发表的导致二次精神病的病变的功能联系.
- 使用计算分析与与精神病无关的对照病变进行比较.
- 在一个独立的脑损伤患者队列和神经行为测试中的验证.
主要成果:
- 造成二次精神病的病变始终被映射到与海马后部垂体连接的功能性大脑电路中.
- 这一电路包括腹部体区域,后皮质,小脑和丘脑.
- 一个独立的队列显示了与精神病症状相关的病变的相似连接概况,突出显示了前额叶皮质的前额叶皮质作为潜在的神经调节目标.
结论:
- 导致二次精神病的病变会影响以海马为中心的共享大脑电路.
- 已识别的电路和特定区域,如前额外皮质的前额外皮质,为精神病的治疗神经调节提供了有希望的目标.
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