高阶的体输入到皮层可以选择性地传递状态信息
Garrett T Neske1, Jessica A Cardin1
1Department of Neuroscience, Kavli Institute for Neuroscience, Wu Tsai Neuroscience Institute, Yale University, New Haven, CT, USA.
不仅仅是皮质皮层的,更高阶的甲状腺皮层投射也会显著影响视觉皮层的功能. 这些通路传达全球兴奋状态,调节感官处理.
科学领域:
- 神经科学是一个神经科学.
- 视觉系统 视觉系统
- 甲状腺皮层的途径
背景情况:
- 新皮质沟通传统上依赖于直接的皮质皮质连接.
- 泰拉马斯,特别是高阶核,也向皮质投射,这表明它在皮质皮质沟通中发挥了作用.
- 这些甲状腺皮层路径对高阶皮层功能的具体贡献尚不清楚.
研究的目的:
- 调查皮质皮层和更高层次的甲状腺皮层输入在后部中部视觉皮层 (PM) 中的不同作用.
- 阐明更高层次的乳头核对视觉处理和皮层通信的功能影响.
主要方法:
- 在小鼠模型中利用神经元和轴突终端的体内成像.
- 采用光遗传学操纵来选择性地激活或抑制特定的神经通路.
- 专注于高阶视觉丘脑及其投射到后部中部视觉皮层 (PM).
主要成果:
- 从较低区域的皮质皮质突出向PM传递强大的视觉信息.
- 高阶的甲状腺皮层投影传递有关全球兴奋状态的信息.
- 证明了更高层次的丘脑对PM功能的独特影响.
结论:
- 高阶质在向视觉皮层提供上下文信号方面发挥着至关重要的作用.
- 甲状腺皮层路径有助于灵活调节皮层感官处理,超出直接视觉信息中继.
- 这突显了前来被低估的马体在复杂的认知功能中的重要作用.
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