氨酸通过增强胚胎IL-5分泌来调节母胎免疫耐受性和子宫内膜受容性
Shuang Cai1, Bangxin Xue1, Siyu Li1
1State Key Laboratory of Animal Nutrition and Feeding, Ministry of Agriculture and Rural Affairs Feed Industry Center, China Agricultural University, Beijing, China; Frontier Technology Research Institute of China Agricultural University in Shenzhen, Shenzhen, China.
孕产妇摄入的 metionin 通过促进互白素-5 (IL-5) 的产生,提高了怀孕的结果. 这提高了免疫耐受性和子宫受容性,为成功怀孕提供了一个营养策略.
科学领域:
- 生殖生物学 生殖生物学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 成功怀孕取决于子宫内膜受体性和母胎免疫耐受性.
- 这些过程背后的具体营养机制在很大程度上是未知的.
研究的目的:
- 为了研究孕妇甲因在怀孕后果中的作用.
- 阐明连接 metionin,免疫耐受性和子宫内膜受体性的分子机制.
主要方法:
- 评估了母亲的 metionin 供应对怀孕结果的影响.
- 测量了中白素-5 (IL-5) 度.
- 分析了CD4+ T细胞分化成IL-5+ Th2细胞.
- 研究了核因子 κB (NF-κB) 途径和整合素 αvβ3 表达的激活.
- 检查了 metionin 对eomesodermin (Eomes) DNA 的甲基化和转录的影响.
主要成果:
- 母体氨酸显著改善了怀孕结果,与IL-5水平相关.
- 氨酸诱导胚胎IL-5分泌,促进Th2细胞分化,增强免疫耐受性.
- 甲因介导的IL-5激活了NF-κB通路,并增加了子宫内膜整合素αvβ3的表达,改善了受体性.
- 氨酸影响了Eomes的DNA甲基化和转录,影响了IL-5促进剂活性.
结论:
- 通过调节IL-5分泌,孕产妇的 metionin 对于成功怀孕至关重要.
- 氨酸通过依赖IL-5的途径增强了母胎免疫耐受性和子宫内膜受容性.
- 氨酸对Eomes的影响是调节IL-5转录,免疫耐受性和受体性的关键,这表明潜在的营养干预.
更多相关视频
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
08:50A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
相关概念视频
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
MicroRNAs
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
