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来自瘤细胞外囊泡的PD-L1通过重编程脂质代谢促进T细胞衰老

Feiya Ma1,2, Xia Liu3, Yuanqin Zhang3

  • 1Division of Infectious Diseases, Allergy & Immunology and Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.

Science translational medicine
|February 12, 2025
PubMed
概括

含有PD-L1的瘤细胞外囊泡 (tEVs) 会导致T细胞功能障碍和衰老. 抑制tEVs或准脂质代谢和CREB信号增强了癌症免疫治疗的有效性.

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