标本性肥胖和阿尔茨海默病之间的联系:来自大脑的神经营养因子的观点
Emily N Copeland1,2, Paul J LeBlanc2,3, Paula Duarte-Guterman4,5
1Department of Kinesiology, Brock University, St. Catharines, ON, Canada.
The Journal of physiology
|February 12, 2025
概括
减少来自大脑的神经营养因子 (BDNF) 可能会将sarcopenic肥胖和阿尔茨海默病 (AD) 联系起来. 较低的BDNF影响肌肉,新陈代谢和大脑健康,这表明它是与年龄有关的疾病的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 代谢性疾病是一种代谢性疾病.
背景情况:
- 随着全球寿命的延长,与年龄相关的疾病,包括sarcopenic肥胖症和阿尔茨海默病 (AD),正在增加.
- 标记性肥胖症,以肌肉损失和体重增加为特征,增加并发病风险,特别是AD.
- 萨科佩尼性肥胖症和阿尔茨海默病之间的确切联系尚不清楚.
研究的目的:
- 探讨降低脑衍生神经营养因子 (BDNF) 水平是萨科佩尼克肥胖和阿尔茨海默病 (AD) 之间的联系的基础.
- 审查BDNF在AD病变发生,骨肌肉健康和代谢调节中的作用.
主要方法:
- 文献综述检查了BDNF在AD病理学中的作用.
- 分析BDNF对骨肌肉功能和线粒体健康的影响.
- 研究BDNF与胰岛素抵抗,脂肪和脂肪组织标记物的关系.
主要成果:
- 在AD中减少的BDNF信号与粉样蛋白β (Aβ) 和神经纤维状结 (NFT) 的增加有关.
- 骨肌肉中较低的BDNF会损害修复和再生,导致肉症.
- 缺乏BDNF会对线粒体功能产生负面影响,促进胰岛素抵抗,体重增加和脂肪.
结论:
- BDNF可能会减轻AD病理,改善骨肌肉功能,胰岛素耐药性和脂肪.
- 对于多种与年龄相关的疾病,BDNF是一个潜在的治疗标.
- 需要进一步的研究,特别是对生物性别的影响,因为女性面临着更高的阿尔茨海默病和肉骨肥胖的风险.
相关概念视频
Alzheimer's Disease: Overview
432
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
432
Neural Regulation
39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
Enzyme-linked Receptors
77.1K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
77.1K
Biological Causes of Schizophrenia
35
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
35


