慢性阻塞性肺病患者中长期接受催眠的发生率和预测因素
Jason M Castaneda1, Aristotle Leonhard2, Laura J Spece3,4
1University of Washington, Division of Pulmonary, Critical Care, and Sleep Medicine, Seattle, Washington, United States; jasonc9@uw.edu.
Annals of the American Thoracic Society
|February 12, 2025
概括
慢性阻塞性肺病 (COPD) 患者长期使用催眠药物很常见,尽管有指导方针. 呼吸系统症状和心理健康问题可能导致这种做法.
科学领域:
- 肺部医学 肺部医学
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 患有慢性阻塞性肺病 (COPD) 的患者经常接受治疗失眠的催眠处方.
- 临床指南建议短期使用催眠药,但长期处方在COPD患者中很常见.
- 由于COPD的潜在不良影响,了解长期使用催眠的发生率和预测因素至关重要.
研究的目的:
- 确定COPD患者长期使用催眠药物的发生率.
- 为了确定与COPD中与指导方针不一致的长期催眠处方相关的患者和现场水平的因素.
主要方法:
- 分析了2010-2019年全国退伍军人健康管理局的数据.
- 确定了新开始接受催眠药 (zolpidem,美拉,特拉佐,doxepin) 的COPD患者.
- 长期使用被定义为在随后的90天内持续使用催眠药30天以上.
- 混合效应物流回归评估了长期催眠接收的预测因素.
主要成果:
- 超过一半 (55.6%) 的COPD患者新处方的催眠药长期服用.
- 长期使用与短效β-激动剂,维持性吸入剂和心理健康诊断 (PTSD,抑郁症,焦虑症) 的使用增加有关.
- 频繁的初级保健访问预测了长期的催眠使用,而初始的黑激素使用和肺部访问是保护性的.
结论:
- 长期的催眠处方在COPD患者中很普遍,违反了临床指南.
- 呼吸系统症状负担和精神健康并发症等因素似乎影响了长期的催眠处方.
- 未来的干预措施应解决这些并发症,以减少COPD中不适当的长期催眠使用.
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