Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genomics02:02

Genomics

35.7K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.7K
Proteomics01:33

Proteomics

7.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.2K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

GFP reporter system reveals cell-to-cell variability in aquaporin-2 expression.

American journal of physiology. Cell physiology·2026
Same author

Inducible <i>Avp</i> knockout mouse line.

American journal of physiology. Renal physiology·2025
Same author

CREB-Family Transcription Factors and Vasopressin-Mediated Regulation of Aqp2 Gene Transcription.

Journal of the American Society of Nephrology : JASN·2025
Same author

CREB-family transcription factors and vasopressin-mediated regulation of <i>Aqp2</i> gene transcription.

bioRxiv : the preprint server for biology·2025
Same author

Downloadable tool for modeling of salt, urea, and water transport in a renal tubule segment: application to the DCT.

American journal of physiology. Renal physiology·2025
Same author

A distal convoluted tubule-specific isoform of murine SLC41A3 extrudes magnesium.

Acta physiologica (Oxford, England)·2025

相关实验视频

Updated: May 28, 2025

Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

941

利用Omic数据来理解整合生理学.

Mark A Knepper1

  • 1Epithelial Systems Biology Laboratory, Systems Biology Center,National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.

Physiology (Bethesda, Md.)
|February 12, 2025
PubMed
概括
此摘要是机器生成的。

分子生理学使用Omic技术,如质谱和下一代测序 (NGS) 来获得详细的数据. 将这些数据与传统研究相结合,是理解全生物体生理学的关键.

关键词:
贝叶斯定理 贝叶斯定理有关因果关系的图表.数据库就是数据库.大型语言模型.自然语言处理自然语言处理.蛋白质组学 蛋白质组学翻译学 翻译学 翻译学 翻译学

更多相关视频

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.1K
A Multi-Omics Extraction Method for the In-Depth Analysis of Synchronized Cultures of the Green Alga Chlamydomonas reinhardtii
07:51

A Multi-Omics Extraction Method for the In-Depth Analysis of Synchronized Cultures of the Green Alga Chlamydomonas reinhardtii

Published on: August 8, 2019

7.6K

相关实验视频

Last Updated: May 28, 2025

Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

941
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.1K
A Multi-Omics Extraction Method for the In-Depth Analysis of Synchronized Cultures of the Green Alga Chlamydomonas reinhardtii
07:51

A Multi-Omics Extraction Method for the In-Depth Analysis of Synchronized Cultures of the Green Alga Chlamydomonas reinhardtii

Published on: August 8, 2019

7.6K

科学领域:

  • 身体生理学 身体生理学
  • 生物信息学是一种生物信息学.
  • 系统生物学 系统生物学

背景情况:

  • 生理学研究已经转向缩小主义和分子生理学.
  • 欧米技术 (质谱学,下一代DNA测序) 产生了大量的生物数据.
  • 了解整个生物体的生理学仍然是一个挑战,尽管有Omic的进步.

研究的目的:

  • 审查与生理学相关的Omic技术.
  • 探索合并Omic和基于假设的研究数据的挑战.
  • 讨论用于生理学理解的大规模数据集成方面的进展.

主要方法:

  • 总结主要的蛋白质质谱和NGS技术.
  • 描述数据整合策略:欧米数据资源,贝叶斯方法,自然语言处理.
  • 审查大型语言模型 (LLM),如ChatGPT,用于知识集成.

主要成果:

  • 在线Omic数据资源民主化访问.
  • 贝叶斯方法将Omic和假设驱动的数据用于特定问题.
  • 自然语言处理有助于文学分析和因果图的创建.

结论:

  • 整合多样化的Omic和传统数据对于推进生理学理解至关重要.
  • 新的计算方法,包括LLM,显示出希望,但对生理数据有局限性.
  • 需要进一步开发,以充分利用Omic数据来获得整体的生理洞察力.